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A patient with increasing pain and edema in his left leg. In a recent hospital admission he was diagnosed with myeloma. This case reviews pretest probability of deep vein thrombosis, D-dimer and interpretation of compression ultrasound.
Last week when I came onto a day shift I was handed over a patient who was waiting for an ultrasound scan.
He was a 65 year old man who presented at midnight to the emergency department, 6 days after being discharged from hospital. He was diagnosed with multiple myeloma during this 10 day hospital stay. He received radiation therapy to his shoulder because of a painful mass and had not yet started systemic treatment for the myeloma.
The patient came to the emergency department because he had noticed increasing swelling of his left leg, with discomfort in the medial thigh.
His vital signs were all normal. He was fully mobile and kept going outside for a cigarette. He had bilateral pitting edema of the ankles which was worse on the left lower leg than the right. There was no tenderness in the distribution of the deep calf veins although he was tender in the medial mid-thigh. There were no other signs of deep vein thrombosis (DVT).
Clinical probability estimation
No diagnostic test is either 100% sensitive or 100% specific. As physicians, we can’t diagnose or exclude a condition without considering the results within the clinical context of our individual patient. This is Bayes theorem, which uses the pretest probability of a condition to calculate the probability of the patient having the disease after a positive or negative test. For example, it is easy to forget that ultrasound can give false positive results when the patient has ‘chronic DVT’ (a fibrous scar remnant of a prior clot), and false negative results (especially if ultrasound does not routinely examine calf veins). Pretest probability estimate should be the first test when a physician assesses a patient for DVT. In general, this can be done by using the Wells score 12 (detailed in Table 1 below) or by gestalt (global) estimation. The pretest probability should always be recorded in the medical record.
|Table 1: Wells score for DVT|
|Cancer (active or palliative treatment in the last 6 months)||1|
|Immobility (bedbound for 3 or more days) or surgery requiring general anesthetic in past 4 weeks||1|
|Immobility of the affected leg (cast, splint, paralysis)||1|
|Previous episode of venous thrombosis (DVT, PE or unusual site thrombosis such as cerebral, mesenteric veins)||1|
|Affected calf >3cm larger than the normal leg (measure 10cm below each tibial tuberosity)||1|
|Prominent superficial veins on the affected leg, compared to the unaffected leg (do not count varicose veins)||1|
|Entire leg swollen (from groin to toe)||1|
|Tenderness within the calf muscles or else in the medial thigh (distribution of deep veins)||1|
|Pitting edema seen only in the affected leg||1|
|Another diagnosis is equally or more likely than DVT||-2|
|DVT unlikely ≤1 point DVT likely 2 or more points|
Although the patient had some features consistent with DVT, it was not clear to me that he was high risk. To clarify this I calculated his Wells score for DVT. Remembering the components of the Wells score can be challenging during a shift, so always look up the score or use a calculator.
He scored points for cancer and tenderness of the thigh. I also gave him a point for immobility since he had been recently admitted to hospital. When I questioned him, at the time of admission he was too weak to walk around the ward. His total was 3 points which placed him in the ‘DVT likely’ category.
D-dimer is most often used to exclude DVT or pulmonary embolism (PE) in patients with a low risk of venous thrombosis. In this case, I couldn’t use D-dimer to exclude DVT because of the higher pretest probability. This is an example of using Bayes theorem. Generally speaking, a D-dimer can exclude venous thrombosis if the pretest probability is under 15% (or ‘DVT unlikely’)3. His probability of having DVT was too high for a normal D-dimer test to exclude the condition.
However, I did order a D-dimer. My reasoning for this was to help me interpret the results of the compression ultrasound scan.
The ultrasound revealed that this patient had a 12cm x 3cm mass in the mid left thigh. The leg veins compressed normally from the external iliac vein to the calf trifurcation.
Our hospital does not perform ultrasound of the calf veins. In this case, a single negative proximal ultrasound may not exclude a DVT completely. If this patient had had a ‘complete leg’ ultrasound, including all calf veins, I could have been confident that he had no DVT. However, in order to exclude DVT properly, I needed to review his Wells score and his D-dimer (see Table 2 below). Because the patient had a ‘DVT likely’ Wells score AND a D-dimer of 1760 (cutoff 500), I arranged for a repeat ultrasound scan in 7 days time.You should know which type of ultrasound is offered in your hospital. Many hospitals offer proximal ultrasound only, in which case you will need the D-dimer and the Wells score pretest probability. This especially important if the ultrasound result will be reviewed by another physician. Be sure to give them the Wells score and the D-dimer.
I discussed the patient with his hematologist, who agreed to review him the next day in clinic. The patient would start chemotherapy in two days time. He was discharged home from the emergency department with an appointment for a repeat ultrasound in a week and no additional treatment.
- Physicians cannot correctly diagnose or exclude DVT without having measured pretest probability of DVT.
- Pretest probability of DVT is accurately and reliably measured using the Wells score for DVT.
- D-dimer and ultrasound results should always be reviewed in the context of the patient’s Wells score.
- Always record the Wells score and D-dimer in the patient chart for better between-physician communication and for medicolegal reasons.
- Know which type of ultrasound is performed by your lab (proximal or complete), and know how to interpret the results.
You are reviewing a patient who has pain in the calf. He flew from home from Australia (a 23 hour journey) three days ago. He has no chest symptoms. He is overweight (BMI 32) but otherwise healthy. He tells you that his father was treated for ‘blood clots’. His leg examination is normal.
Multiple choice questions
Question 1: What is your first action?
A) Order an ultrasound scan
B) Give a dose of low molecular weight heparin and order an ultrasound
C) Order a D-dimer
D) Calculate his Wells score for DVT
E) Send him to a specialist clinic such as Thrombosis
Correct answer is D. You must calculate his pretest probability of DVT in order to work out if you can use D-dimer to exclude DVT. If so, the patient may not require an ultrasound scan.
Question 2: What is his Wells score for DVT?
A) 1 point because he has been immobile during the journey
B) 2 points because he has a family history of clots and has been immobile during the journey
C) 1 point because he has a family history of DVT
D) 2 points because he has been immobile during the journey and he is obese
E) 0 points as none of the above fulfill the points on the Wells score
Correct answer is E. Family history of venous thrombosis and flights are not components of the Wells score. These are risks for venous thrombosis, however they are not predictive of DVT in the context of the Wells score.
All the content from the Blood & Clots series can be found here.
This post was reviewed by Kira Gossack-Keenan, Teresa Chan and uploaded by Rebecca Dang.