D-Dimer: Should we adjust the cut-off value for age?

In Medical Concepts by Brent Thoma5 Comments

Recently this article flew across my twitter feed via a link from Cliff Reid: Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis (open access BMJ June 2013).   After a quick read of the abstract I was like this: A way to adjust the D-Dimer that preserves sensitivity while increasing specificity? That sounds MORE awesome than peach yogurt! Fewer negative CT’s would only be …