There has been an increase in novel oral anticoagulants (NOACs), which often thought of by many as the non-warfarin anticoagulants. Within this group there are two subclasses:
- Factor IIa (thrombin) inhibitors
- Factor Xa inhibitors
One of our @MacEmerg PGY3 residents, Laura Morrison (no relation to esteemed resuscitation Canadian researcher Laurie Morrison) recently told me about a quick and dirty tip to remember what class each of the NOACs belongs to… and thereby helping you to remember its mechanism of action (MOA).
One of these things is not like the other….
Here is the tip:
Look for the suffix -xaban in the Xa inhibitors in the GENERIC name of the med.
ApiXaban <– Xa inhibitor
RivaroXaban <– Xa inhibitor
Dabiagatran <– NO “Xa” therefore not a Xa inhibitor. (Direct thrombin inhibitor) does not, therefore, fit within this model!!
Laura says you can think of it as “banning” the Xa factor to the abyss…
(NB: This does not work for the trade name…)