CanMEDS Roles addressed: Expert Main Messages At standard doses DOACs are safe and effective for most patients and lab monitoring is not required for routine use. If the time of the last dose is known, an estimate of current anticoagulation effect can be obtained by measuring the number of half-lives that have elapsed in those with normal renal function. If the last ingestion is unknown, an estimate of current anticoagulation effect can be … Continue reading Blood & Clots Series: How do I determine if my patient on a DOAC is still at increased risk of bleeding?